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doi: 10.1093/milmed/167.8.701

IGF-1 LR3 suppresses endogenous growth hormone and IGF-1 production via negative feedback inhibition at the hypothalamus and pituitary

Semaglutide: The GLP-1 Pathway Semaglutide is a GLP-1 receptor agonist with 94% homology to native GLP-1 and a ~7-day half-life achieved through C18 fatty acid acylation and DPP-4 resistance (Muller et al., 2021)