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Typically, it is administered intramuscularly (IM), ensuring rapid absorption and bioavailability

In specific embodiments, any formulation or composition described herein has a pH that allows for terminal sterilization (e.g., by heat treatment and/or autoclaving) of a formulation or composition without degradation of the therapeutic agent

This results in faster bioavailability, potentially accelerating the onset of its regenerative and anti-inflammatory properties, key areas of interest in clinical and preclinical research

It has also been reported that an ACI procedure may prevent the progression of early osteoarthritis in patients with cartilage injuries (Jungmann et al., 2019)