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Factors that may contribute to interstitial cystitis (IC): Inflammation and mast cell activation Inflammation can release chemicals that disrupt the integrity of the bladders epithelial surface leading to mast cell activation and ultimately giving rise to pain and voiding dysfunction

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A 2021 study in Gut found that long COVID patients had significantly reduced microbiome diversity and specific depletions in beneficial species, including Faecalibacterium prausnitzii and Bifidobacterium bacteria known for their anti-inflammatory and immune-regulatory properties