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Obesity & Metabolic Syndrome Research in Diet-Induced Obesity (DIO) models shows a 12% reduction in total body weight and a 10-fold reduction in fat accumulation

Conflict of Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

Symbiotic gut bacteria also supplement animals endogenous polyamine production, especially but not exclusively via the Agm synthetic pathway, though to what extent polyamines from this source reach the brain is not entirely clear (Miller-Fleming et al., 2015)

Peptides fit into the same category because they sound modern, biological and less drug-like