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REDEFINE 1, in adults with overweight or obesity without diabetes, reported 22.7% mean weight loss for the combination at 68 weeks on the on-treatment analysis, with 60% of combination participants reaching at least 20% loss and 23% reaching at least 30% (Aronne et al., 2025)

doi: 10.1016/j.yexcr.2020.112061 91 ChangCCHungCMYangYRLeeMJHsuYC

Nitric oxide and hydrogen sulfide regulation of ischemic vascular remodeling

Despite the positive effects on weight gain, preconception RPM supplementation may have reduced subcutaneous fat deposition in the offspring, indicating a possible shift in energy partitioning toward lean tissue accretion (Heredia et al, 2025b)