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According to meta-analysis data, hypothyroidism occurs in about 3.8% of patients treated with anti-CTLA-4, 3.9% with anti-PD-L1, 7.0% with anti-PD-1, and 13.2% with combination therapy

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Medical therapies that can stimulate endogenous testosterone production include hCG [human chorionic gonadotropin], AIs [aromatase inhibitors], and SERMs [selective estrogen receptor modulators] , all of which demonstrate efficacy in increasing serum testosterone levels and good safety profiles

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