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This means well-characterized chemistry, demonstrated mechanism, clear clinical efficacy, and safety equivalent to current drugs

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When managing patients taking opioid analgesics, particularly those who have been treated for an extended period of time and/or with high doses for chronic pain, ensure that a multimodal approach to pain management, including mental health support (if needed), is in place prior to initiating an opioid analgesic taper

Distinct types of tumor-initiating cells form human colon cancer tumors and metastases