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Consuming more than 3 units/day (12-13 g alcohol/unit) increases the likelihood of cirrhosis in both men (OR 4.3) and women (OR 5.7), with a multiplicative interaction between alcohol intake and HBsAg positivity further elevating the risk (8)

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Mechanisms include: Restoration of endothelial nitric oxide synthase (eNOS) Upregulation of VEGF and FGF-2 (fibroblast growth factor 2) Reduction of oxidative stress and cytokine-induced apoptosis BPC-157 preserved endothelium-dependent vasodilation via upregulation of eNOS and suppression of vascular inflammation. Gwyer Findlay et al., Peptides 4

Additionally, curcumin may influence ion channel activity, such as TRPM2, which is implicated in tumor progression and represents a promising therapeutic target in oncology ( Hormonal and metabolic effects Curcumin modulates several endocrine and metabolic pathways, notably those involved in insulin signaling and sex hormone regulation