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Brain-derived neurotrophic factor (BDNF) is a key regulator of neuronal survival and synaptic plasticity,exposure to microplastics induces significant downregulation of BDNF gene expression, leading to morphological and functional impairments in prefrontal cortical neurons, which may consequently affect cognitive and emotional functions, microplastics directly disrupt neuronal function by triggering oxidative stress and cellular damage (14, 15)

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Upon zinc binding, MTF-1 undergoes a conformational change that facilitates its nuclear translocation and binding to MREs in the promoter regions of target genes [146]