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This concern can be effectively addressed by applying hydroquinone cream to the affected area

When NF-kB translocates to the cell nucleus, it switches on the transcription of pro-inflammatory cytokines including TNF-alpha, IL-6, and IL-1-beta

Through inhibiting the NF-B pathway, sulforaphane also targets other mediators of the inflammatory response, including the enzymes cyclooxygenase-2 (COX-2), prostaglandin E (PGE) synthase, and inducible nitric oxide synthase (iNOS)

Although there are recommended therapies for AD, such as acetylcholinesterase inhibitors and the N -methyl-D-aspartate receptor antagonists, they are inefficient and do not prevent disease progression, reflecting our incomplete understanding of AD pathogenesis