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Commoner, B., Townsend, J

The JAK/STAT signaling pathway, as the main target for inhibiting the action of a variety of cytokines (221), is involved in the signal transduction of many key cytokines for the pathogenesis of RA and has been considered as a potential target for the treatment of RA (222)

Activated JNK facilitates the translocation of pro-apoptotic proteins Bax and Bak to the mitochondria and simultaneously inhibits the anti-apoptotic activity of Bcl-xL, thereby indirectly triggering the mitochondrial apoptotic pathway

Common reconstitution mistakes and how to avoid them Mistakes during reconstitution are not theoretical