The GSH-Fe-S cluster-OXPHOS axis GSH is indispensable for mitochondrial homeostasis and the biogenesis and stability of Fe-S clusters, thereby sustaining OXPHOS and cellular energy metabolism 16,17,203
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These linkers are designed to be relatively stable at physiological pH (~7.4) but undergo hydrolysis in the acidic endosomes or lysosomes (pH 4.56.0) of tumor cells
It is widely used in in-vitro experimental models focused on proteinpeptide interactions, cellular regeneration pathways, mitochondrial activity, and receptor-binding behavior