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The life cycle of skin melanocytes consists of several steps, including lineage specification from embryonic neural crest cells (melanoblasts), migration and proliferation of melanoblasts, differentiation of melanoblasts into melanocytes with dendritic morphology 23

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The pathogenesis of OA involves coordinated activity among multiple pathways, including mTOR, IL-6-STAT3, and EVs, which collectively promote cartilage degeneration and inflammatory responses