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Vitamin B12 deficiency can lead to severe health consequences, including megaloblastic anemia and neurological disorders, as noted by medical professionals

In fact, recent data suggest that hydrochlorothiazide may inhibit insulin secretion from normal mouse islets by blocking the activity of mitochondrial carbonic anhydrase Vb (Kucharczyk et al., 2023) (see Figure 2)

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Upon arrival at the tumour site, the rapid de-shielding of PEG corona from the nanoparticles triggered by the TME will lead to the exposure of the collagen targeting peptides to anchor the nanoparticles onto the ECM