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Through knowledge obtained by their genetic SNPs, patients can address inconsistencies in their one-carbon metabolism by supplementing nutrients in which they are deficient, or that encourage bypassing problematic aspects of the cycle, such as folinic acid, in order to optimize the efficiency of the methylation and related cycles

Type A reactions generally can be resolved through dosage reduction, precision dosing, or therapeutic drug monitoring

doi: 10.1136/gut.2010.216929 139 KobayashiYOhfujiSKondoKFukushimaWSasakiSKamataNet al

The rate equations for V Gs , V cgshHb , V cgshLb , V GPx , V GR and V gshdeg are taken from Reed et al