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PDPN could also act as a co-inhibitory receptor on T cells, and T cell specific PDPN conditional knockout mice exhibited delayed tumour growth [114]

The dosage of potassium citrate used to prevent kidney stones is generally 12002400 mg per day, a prescription-strength dose that frequently causes digestive upset, making it intolerable for some people (Xu 2013)

This was attributed to spermidines ability to activate mitophagy and autophagy, helping maintain mitochondrial quality and preventing the accumulation of damaged mitochondria in heart tissue (Reference Eisenberg, Abdellatif and Schroeder80)

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