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Although a clear mechanistic perspective is lacking, it can be conceptualized that gut microbial dysbiosis (and its metabolites) modulates innate and adaptive immune players by recruiting immune secreting cells from the appendix, thereby priming the immune system for an enhanced inflammatory response and a possible source of -synuclein misfolding (Masahata et al., 2014

N-acetylcholine receptor(nAChR) Nicotinic acetylcholine receptors (nAChRs) are widely expressed in brain tissue, including brain capillary endothelial cells [71]

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For a common lateral sprain (ATFL), the injection would be on the outer side of the ankle