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While early nonresponse is considered to be an indicator of later nonresponse and subsequent treatment resistance in schizophrenia [67], to our knowledge, the association between early nonresponse in first-episode samples and later sequential treatment failures and the status of conventionally defined TRS is yet to be established

10.1186/s12951-025-03109-3 99

Mazdutide, Innovent Biologics/Eli Lilly