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KS, GZ, HJ, VA, and AK edited and provided critical feedback for approval of the final manuscript

A 2025 human pilot study reported no adverse cardiac, hepatic, or renal effects at IV doses of 10-20mg

Signs You May Benefit from HRT In Women Hot flashes or night sweats disrupting sleep Mood changes anxiety, irritability, depression without an obvious cause Brain fog or difficulty concentrating Fatigue that doesnt resolve with rest Vaginal dryness, discomfort during sex, or decreased libido Weight gain around the midsection despite no change in diet or exercise Irregular or absent periods (perimenopause) In Men Low energy or persistent fatigue Decreased libido or erectile changes Loss of muscle mass and increased body fat Mood changes depression, irritability, reduced motivation Brain fog or difficulty with memory and focus Poor sleep and reduced exercise recovery These symptoms require lab confirmation before a protocol is prescribed