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The comparison of our structures with known mu class GST structures show differences in the location of the electrophile-binding site (H-site), explaining the different substrate specificities of the two classes

Over time, this chronic depletion also forces the body to break down skeletal muscle tissue to harvest stored glutamine, leading to the muscle wasting, profound weakness, and exercise intolerance frequently observed in complex chronic illnesses

A systematic review proposed that patients may benefit from rigorous retesting of several agents (e.g., drugs such as -lipoic acid, duloxetine, glutathione, and vitamin E) to extend and validate the evidence of American Society of Clinical Oncology (ASCO) recommendations for CIPN management [82]

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