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Interestingly, BBB restoration has been observed by integrating pericytes, potentially indicating a direct cell replacement of the BBB components, but also by neural or mesenchymal stem cells, which likely suggests an indirect paracrine effect

4 The performance of seeds and seedlings under HM stress While the seed coat initially offers some defense against metal stress before germination, it will gradually rupture or become more porous throughout the germination process (Kranner and Colville, 2011)

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