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These variations can affect how efficiently your kidneys handle excess B12, creating individual thresholds that vary quite a bit between people

An inflammatory arthritis in children that lasts for at least six weeks, which is not caused by other known types of arthritis

10.1016/j.cellimm.2023.104754 78

Dogs treated with pyridoxine obtained a median cumulative dose of 4.7 mg/kg (mean, 4.1 mg/kg) compared to the 5.0 mg/kg cumulative goal dose, while dogs treated with placebo received a median of 2.75 mg/kg (mean, 2.9 mg/kg