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Furthermore, studies performed in endothelial cells, Kaposis sarcoma-associated herpesvirus (KSHV)-transformed cancer cells and several normal fibroblast or epithelial cell lines reported a similar effect of asparagine on supporting cell survival and protein translation after glutamine deprivation 44,49,50

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This model provides a more systematic and dynamic perspective for understanding the progression of AD from a compensable early phase to an irreversible advanced stage, thereby laying a theoretical foundation for developing precision combination therapies tailored to different disease stages

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