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CCO is the terminal enzyme in the mitochondrial electron transport chain (ETC) ( During PBM for KOA, this molecular cascade activates CCO in synovial macrophages, releasing NO that collectively restarts mitochondrial respiration and initiates downstream signalling networks ( Figures 1 , 2 )

Powerful Antioxidant Oxidative stress occurs when there is an imbalance between the production of free radicals and the body's ability to counteract them

PACS-related PF could be also caused by pneumonia induced by either acute respiratory distress syndrome (ARDS) or COVID-19, thus the patients could benefit from the treatment of IPF (Duong-Quy et al., 2023)