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These structural distinctions, in turn, may contribute to the distinct pharmacological profile of Cagri when assessed in proximal, selective, assays of primary transducer interaction

Consequently, bisphosphoglycerate phosphatase activity is favored over the kinase activity and leads to the depletion of 2,3-diphosphoglycerate (2,3-DPG), which in turn negatively impacts oxygen binding and off-loading kinetics 13,14

These findings have significant implications for developing supportive care protocols that reduce long-term chemotherapy side effects and improve quality of life for cancer survivors