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The finding starkly contrasts with earlier literature, which views the city-region as the result of an organic process rather than a normative construct, and highlights the critical need to discuss the methodologies that contribute in selecting the components that constitute a relevant city-region

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In a mouse model of hepatocellular carcinoma induced by diethylnitrosamine (DEN), liver GCN5L1 knockout increased DEN sensitivity in the model

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