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The loss-of-function mutations of TP53 occur in close to 100% of HGSC cases [110]

In specific secondary analyses we examined the impact of antidepressant use, measured based on drug container inspection of medications used in the past month, classified according to the World Health Organization Anatomical Therapeutic Chemical classification: selective serotonin reuptake inhibitors (N06AB), tricyclic antidepressants (N06AA) and other less commonly prescribed medications (N06AX, N06AF, N06AG)

However, these findings were not validated in animal models, and key pharmacological parametersincluding fertility outcomes, long-term toxicity, and pharmacokineticsremain uncharacterized