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To generate AdipoQ-CreERT2 x p53-Lox mice, female mice heterozygous for the CRE-transgene and homozygous for loxP-flanked allele were bred with male mice homozygous for loxP-flanked allele starting at the age of 10 weeks

This destructive oxidative process is considered a central mechanism of ferroptosis, iron overload accelerates the production of ROS via the Fenton reaction, which in turn amplifies lipid peroxidation, compromising the cell membrane and leading to ferroptosis

10.1183/09031936.02.00267402 130 PengL.LeiZ.RaoZ.YangR.ZhengL.FanY.et al (2021)

So, it's not a great biomarker for long-term omega-3 status