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5 Cells Mitochondrial-Derived Peptides (MDPs) and cellular health in AMD (Nashine & Kenney, 2020)Review of humanin, HNG, MOTS-c and SHLPs as cytoprotective mitochondrial-derived peptides, including their role in age-related macular degeneration models

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Simultaneously, nicotinamide is consumed reducing the substrate available for the salvage pathway to regenerate NAD+

As such, depending upon the otic agent used, the thickness or viscosity desired, or the mode of delivery chosen, alternative aspects of the embodiments disclosed herein are combined with the immediate release, delayed release and/or extended release embodiments accordingly