Tan X, Liu Q, Fang Y, Yang S, Chen F, Wang J, et al
Sources of depletion can include: Mitochondrial energy production (a normal and essential process, but creates harmful byproducts like ROS) Chronic infections, gut dysbiosis (including SIBO and Candida ), and ongoing inflammation Air pollution, heavy metals, and environmental toxins 17 Ultra-processed foods, sugar-sweetened beverages, and foods high in advanced glycation end products (heavily browned foods) 18 Pesticides and herbicides 19 Alcohol and smoking Psychological stress Even vigorous exercise (a healthy stressor that still creates oxidative byproducts) 20 Understanding this helps explain why simply eating well sometimes isnt enough, and why targeted nutritional strategies make a meaningful difference
Standard dose: 5001000 mg per day During intense training or cutting: up to 2000 mg per day (split into two doses) Cycle length: 48 weeks, extend if needed Better dont do more than 2000 mg per day
For some xenobiotics, the toxicity may involve biliary and oval cells (Figure 9), produce cholestasis, or be associated with vascular occlusive changes and granulomatous inflammation
