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[1] A review of literature shows that the prevalence of PA is higher in Northern Europe, especially in Scandinavian countries, and among people of African descent, and that increased awareness of the disease and better diagnostic tools might play a role in apparently higher rates of incidence

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10.3389/fnins.2023.1209527 [DOI] [PMC free article] [PubMed] [Google Scholar] Barnes P

It may be considered in cases involving: Chronic infections Immune dysregulation Persistent inflammatory states Because chronic immune activation can perpetuate inflammation, addressing underlying immune stressors is often essential