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L-Citrulline, on the other hand, seems to produce equal or better results, plus it completely bypasses the liver and the whole arginase conversion process

Because NF-B is an activator of many pro-inflammatory cytokines, including IL-6 (32), this could contribute to increased inflammation and the cytokine storms observed in COVID-19, and be a significant basis of pathogenic effects associated with SCoV2 infection of various tissues, including the lung, gastrointestinal tract and cardiovascular system

Drug delivery to the brain To overcome the BBB, various approaches have been developed for the delivery of a therapeutic to the brain