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2.3 Physiological role of ROS ROS are very important molecules as they act as cellular mediators essential for (1) normal spermatogenesis, (2) activation of steroidogenic pathway, (3) modulation of mitochondrial and death receptor-apoptotic pathways

It is evident from a growing number of studies that high-fat diets, drugs (antibiotics), and toxicants induce dysbiosis and improve the survivability of normally uncommon gut microbial species, leading to enhanced functional responses, pathogen infiltration, and further deterioration of gut health (Desai et al., 2016)

Moreover, dysregulation of the tumor suppressor, p53, combined with upregulation of anti-apoptotic genes was linked to lower apoptosis in keloids 5,6

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