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Why Storage Conditions Determine Whether Your Peptides Actually Work Peptides are short chains of amino acids, and that structural simplicity is also their vulnerability

PLoS ONE 9:e115213 Kaverina I, Krylyshkina O, Small JV (1999) Microtubule targeting of substrate contacts promotes their relaxation and dissociation

Mitochondrial mass assessed by NAO staining in ( a ) HCT116 cells treated with TS-targeting therapies, ( b ) non-small cell lung cancer (NSCLC) cell lines treated with pemetrexed, ( c ) HCT116 cells treated with 5FU, FOLFOX (5FU+oxaliplatin), FOLFIRI (5FU + SN38), or single agent oxaliplatin and SN38, or ( d ) HCT116 cells treated 5FU Torin or rapamycin for 72 h

Then, in 2015, Lee and colleagues identified a previously overlooked open reading frame within the 12S ribosomal RNA gene of mtDNA and found that it encodes a functional peptide, MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) [1]