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3.3.5 Antioxidant proteins as potential therapeutic targets for ferroptosis in DN Ferroptosis in DN is governed by a core network of antioxidant proteins, with Nrf2 as the master transcriptional regulator

10.3390/biom10101360 193 YinW.YangL

demonstrated that Tom20 or Bax knockout effectively blocks ROS-induced pyroptosis, while antioxidant treatment significantly reduces Tom20 oxidation, Bax mitochondrial recruitment, and GSDME cleavage, further confirming that ROS serves as the central regulator of this signaling pathway (47)

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