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This medication is not recommended during pregnancy due to potential risks to fetal development
Medications were unchanged for at least 4 months before and during the study
During titration, it is not recommended to increase by more than 2.5 mg every 4 weeks to avoid side effects
The functional antagonism between Th17 cells and Treg cells primarily manifests in their reciprocal interactions and regulatory mechanisms within the immune system ( Treg cells mainly fall into four categories and use direct or indirect interaction to carry out immunosuppressive actions: 1) Cytokine-mediated suppression: TGF-, IL-10, and IL-35 induce Treg development, prevent antigen-presenting cell (APC) maturation, and mediate bystander suppression ( 3 Metabolic programs governing the Th17/Treg balance Metabolic reprogramming critically controls Th17 and Treg cell fate
