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References 1 Pharmaceuticals (Basel)Clinical evidence for targeting NAD+ therapeutically: metabolic pathways and therapeutic potential

Any benefits achieved through supplementation may gradually diminish over time if healthy lifestyle habits and nutritional support are not maintained

Its mechanisms include: Promoting Satiety : Activates receptors in the brain to enhance feelings of fullness, helping to naturally reduce food intake ( 1, 2 )

Further, studies have indicated the upregulation of LOXL2 in OA cartilage in response to injury, which may be considered as a naturally protective response that promotes anabolism while inhibiting specific catabolic response during OA pathophysiology (Tashkandi et al., 2019)