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In silico modelling suggests that rs146558 is a nonsynonymous single nucleotide polymorphism that leads to disruption in protein function

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While a healthy, intact BBB tightly restricts the movement of these substances into the CNS compartment, these, and other myeloid-responsive factors, such as cytokines, are not fully restricted from entering the CNS, which may compromise BBB integrity through stimulation of perivascular Ms and microglia