glucuronidation glutathione Mechanism of the reaction catalyzed by Glutathione-Mediated Conjugation of Anticancer Drugs:

This, in turn, leads to reduced brain tryptophan concentration, decreased 5-HT levels, and diminished 5-HT receptor binding, which may underlie the 5-HT system dysfunction, impaired neurotransmission, and negative cognitive effects observed in SZ

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