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Newborns (especially preterm) lack the ability to metabolize benzyl alcohol, leading to metabolic acidosis, respiratory distress, hypotension and (in reported cases) the often-fatal gasping syndrome. For this reason, only preservative-free sterile water (no benzyl alcohol) is used in pediatric or neonatal care

Immune, primarily antigen-presenting cells of myeloid origin as well as nonimmune cells (Qu et al., 2017) perceive extracellular HSP70 signaling via either C-type lectin or scavenger pattern recognition receptors (PRRs), thereby initiating cytokine release involved in innate immune responses (Murshid et al., 2018)

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In some embodiments, the otic formulation or composition comprises about 5% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof