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Vascular Effects BPC-157 has pro-angiogenic activity in preclinical work, often through VEGF and VEGFR2 signaling, which can enhance tissue microvascular health

Commonly reported side effects from peptide use include mild injection site reactions (redness, discomfort), temporary fatigue, headache, and occasional nausea

A new systematic review published in the HSS Journal (2025) analyzed 36 studies on BPC-157 and found compelling preclinical evidence that it improves healing in muscle, tendon, ligament, and bone injuries, while also reducing inflammation