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Doxiades S.A., Fessas P.H

Claudin-5 is Downregulated by TGF 1 in bEnd.3 Cells As TGF 1 was shown to increase permeability of bEnd.3 monolayers and induce an upregulation of MMP9, further investigation into tight junction protein regulation was warranted

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On the supportive side, the foundational cell-culture work reported that the distinct E-domain of MGF inhibits terminal differentiation of myoblasts while increasing their proliferation a behavior opposite to that of mature IGF-1, and one that would fit the proposed role of expanding the precursor pool before differentiation