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Activation of p53 by MDM2-inhibition sensitizes quiescent blast crisis CML stem/progenitor cells to Bcl-2 inhibitor- and tyrosine kinase inhibitor-induced cell death

The reaction between RT and GSH is based on a Michael addition reaction that is inherently reversible, has an appropriate dissociation equilibrium constant K d in the mM range and rapid reaction kinetics, and provides ratiometric readouts, thus allowing GSH quantification independent of the probe concentration

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