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Indeed, the plight of tens of millions of individuals exposed to iAs in Bangladesh and West Bengal has been described as a public health emergency (Smith et al., 2000) and as the largest poisoning of a population in history (Bhattacharjee, 2007), assessments that are difficult to discount given the number of affected individuals

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Ying Tian, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Cell Death and Survival, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers