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Most participants who experienced nausea reported it during the initial weeks and dose escalation periods, with symptoms improving as the body adapted

Figure 2 Mechanism III Mitochondrial dysfunction can initiate interstitial stone formation (Randalls plaque model)

However, the disparity between mechanistic promise and clinical maturity has direct implications for patient counselling, trial design, regulatory oversight, and ethical considerations surrounding the off-label and grey-market use of these therapies

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