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Increased intra-articular iron levels, lipid peroxidation, and weakened antioxidant defenses promote ferroptosis, worsening cartilage degeneration, and joint function loss ( Although research on the precise mechanisms and clinical relevance of ferroptosis in OA is still in its infancy, the volume of related studies is growing swiftly (Yang et al., 2021

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The agency noted 32 adverse event reports between 2019 and 2024including erectile dysfunction, depression, and suicidal ideationand emphasized that topical application does not eliminate systemic absorption

Martins AJ, Cerqueira MA, Fasolin LH, Cunha RL, Vicente AA