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When it outpaces neutralization by enzymes like superoxide dismutase and small-molecule antioxidants such as glutathione, harm builds up

2.5.1 Regulation of Glucose Metabolism Impaired insulin signaling resulting in altered energy balance and impaired cell repair mechanisms has been observed in PD patients (129131)

For example, focal onset seizures are localized in discrete areas of the brain, usually in one hemisphere, whereas generalized onset seizures immediately engage bilaterally-distributed networks of the brain