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doi: 10.3389/fphar.2022.908772 Received 31 March 2022 Accepted 10 May 2022 Published 24 May 2022 Volume 13 - 2022 Edited by Xu Chen, Guilin Medical University, China Reviewed by Yin Lin Ge, Qingdao University, China Pengyu Chang, First Affiliated Hospital of Jilin University, China Updates Copyright 2022 Zhang, Hou, Chen, Kan, Han, Zhang and Sun

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Beyond its canonical EMP role, PKM2 exhibits reduced catalytic activity, leading to the accumulation of intermediates and their diversion to the PPP for macromolecule biosynthesis, accelerating the proliferation of tumor cells