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Efstratiadis A Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (IGF-1r)

& Bouillaud, F

Studies have found that the reduction of AMPK activity is an important pathological feature of NAFLD, and targeted activation of the AMPK signaling pathway can significantly improve liver lipid metabolism disorders and related pathological injuries (Figure 3)