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As an added precaution for patients with a reaction history within the previous five years, which makes them higher risk, a two-step DOC, starting with 10% of the target dose, is recommended

Izzo JG, Malhotra U, Wu TT, Ensor J, Luthra R, Lee JH, Swisher SG , Liao Z, Chao KS, Hittelman WN, Aggarwal BB, Ajani JA

While primarily beneficial, dysregulation of GST activity or specific isoforms can contribute to disease pathogenesis

Standard dosing Daily dose: 300-600mcg per day Injection frequency: Once daily, preferably in the morning on an empty stomach Administration route: Subcutaneous injection Most users start at 300mcg to assess tolerance, then increase to 500-600mcg if the lower dose is well-tolerated but results are modest